One of the basic reasons that I came to Bocas del Toro and made the decision to begin development is the proximity to the US. There are short, cheap flights from many major cities throughout the US and Canada, as well as Europe. I just took a direct flight from San Jose, Costa Rica to Madrid late last year. Check for flights into either San Jose, Costa Rica or Panama City; Panama City is easier, but there is sometimes a significant price difference.
The local airport has expanded to receive direct international flights sometime in the future. Copa Airlines is talking about this and the plan is to get direct flights to Bocas from Miami, New York, Los Angeles and wherever the hell else will send a flight to a cow pasture.